A practical study exploring new support options in real clinics

This study evaluates digestive health supplements designed to support gastrointestinal function in dogs and cats experiencing diarrhea or loose stools. About the Sponsor: Bimini Animal Health is a U.S.-based manufacturer located in Topeka, KS, focused on developing veterinary-exclusive supplements and health products.

Each patient participates for approximately 14 days, with a single follow-up visit required between days 10–14.

• Dogs and cats with diarrhea lasting >48 hours or a history of recurring loose stools • ≥1 year of age • Dogs: 12–120 lbs | Cats: 5–15 lbs Fecal score ≥3 (soft but still formed stool)

• Patients should not be enrolled if further diagnostics or treatment are warranted. Key exclusions include: • Suspected infectious, parasitic, toxic, or surgical causes (e.g., foreign body) • Concurrent treatments that may influence results (antibiotics, probiotics, GI medications, etc.) • Chronic or systemic disease (e.g., unexplained weight loss, chronic vomiting, suspected IBD/lymphoma) • Pregnant, nursing, or pediatric patients

• Enroll appropriate cases only • Obtain signed owner consent prior to participation • Educate the pet owner on: • Study expectations • Product administration • Risks/benefits and alternatives • Complete pre- and post-study exams • Ensure study data (owner logs + exam findings) is submitted • Report any adverse events to the sponsor

• $200 per completed case paid to the veterinary hospital • (Many clinics split this between the hospital and participating veterinarian) • $100 paid directly to the pet owner Payment is issued after complete study data is submitted.

• 14 days of supplement provided at no cost • Possible support of digestive health and stool quality Note: Clinical benefit is not guaranteed.

• If an adverse event occurs and requires treatment, the sponsor will cover up to $200 per case.

• Yes. Participation is voluntary, and pets may be withdrawn at any time. However, compensation is tied to completion of study data.

• Minimal. Enrollment and exams occur during routine visits, and daily monitoring is completed by the pet owner at home.

• No. Participation does not replace clinical judgment. If a patient requires diagnostics or treatment, they should not be enrolled or should be withdrawn.

• No. Participation does not replace clinical judgment. If a patient requires diagnostics or treatment, they should not be enrolled or should be withdrawn.

• Study data collected (exam findings and owner-reported outcomes) may be used by the sponsor for research and product development purposes. Client and Veterinarian identity remains confidential.

• Patients should be withdrawn and treated appropriately if clinical signs worsen or if additional medical intervention is needed.